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Updated: Aug 15, 2026
09:44
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Improved conditioning regimens for autologous transplantation using targeted radiotherapy
Xingwei Sui1, William Bensinger, Oliver Press
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. xsui@fhcrc.org
Acta Haematologica
|November 5, 2005
Summary
Targeted radiotherapy shows promise in conditioning regimens for autologous stem cell transplants in blood cancers, improving outcomes. However, its effectiveness in solid tumors requires further investigation.
Area of Science:
- Oncology
- Radiotherapy
- Hematopoietic Stem Cell Transplantation
Background:
- Autologous stem cell transplantation is a key treatment for malignant diseases.
- High-dose conditioning regimens often fail to eradicate malignancies, leading to recurrence and death.
- Novel conditioning strategies are crucial for improving transplant efficacy.
Purpose of the Study:
- To review the clinical status of myeloablative targeted radiotherapy in autologous stem cell transplantation.
- To assess the efficacy of targeted radiotherapy in hematological malignancies and solid tumors.
Main Methods:
- Review of clinical studies involving myeloablative doses of targeted radiotherapy.
- Analysis of outcomes in patients undergoing autologous stem cell transplantation for various cancers.
Main Results:
- Targeted radiotherapy with radiolabeled antibodies or bone-seeking isotopes shows encouraging results for lymphomas, multiple myeloma, and bone metastases.
- Less encouraging results were observed with radiolabeled antibodies targeting epithelial antigens on solid tumors.
Conclusions:
- Targeted radiotherapy is a promising component of conditioning regimens for autologous stem cell transplantation in hematological malignancies.
- Further research is needed to optimize targeted radiotherapy for solid tumors in this context.
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