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Updated: Aug 15, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New bis-spirolabdane-type diterpenoids from Leonurus heterophyllus Sw
Phan Minh Giang1, Phan Tong Son, Katsuyoshi Matsunami
1Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, Vietnam.
Abstract:
Twelve natural bis-spirolabdane-type diterpenoids, including eight new, named leoheteronones A-E, 15-epileoheteronones B, D, and E, and four known leopersin B, 15-epileopersin B, leopersin C, and 15-epileopersin C, together with hispanone and galeopsin were isolated from the aerial parts of the medicinal plant Leonurus heterophyllus SW. (Lamiaceae) grown in Vietnam. Their structures were determined by spectroscopic analyses. The current study emphasized the accumulation of C-15 oxygenated bis-spirolabdane-type diterpenoids of both 13R and 13S configurations in L. heterophyllus.
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