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Updated: Aug 15, 2026
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and
Arthur J Moss1, Mary W Brown, David S Cannom
1Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. heartajm@heart.rochester.edu
The MADIT-CRT trial investigates if Cardiac Resynchronization Therapy with a defibrillator (CRT-D) can lower mortality and heart failure (HF) risks by 25% in specific heart patients. This study focuses on individuals with cardiomyopathy and prolonged intraventricular conduction times.
Area of Science:
- Cardiology
- Electrophysiology
- Heart Failure Research
Background:
- Cardiomyopathy and left ventricular dysfunction increase mortality risk.
- Prolonged intraventricular conduction (QRS duration >or= 130 ms) is associated with poor outcomes.
- Cardiac Resynchronization Therapy with a defibrillator (CRT-D) is a potential intervention.
Purpose of the Study:
- To evaluate the efficacy of CRT-D in reducing mortality and heart failure (HF) events.
- To assess the impact of CRT-D in patients with ischemic and non-ischemic cardiomyopathy.
- To determine if CRT-D offers a 25% risk reduction in the target population.
Main Methods:
- The study is the Multicenter Automatic Defibrillator Trial with Cardiac Resynchronization Therapy (MADIT-CRT).
- Inclusion criteria: NYHA class I-II (ischemic) or NYHA class II (non-ischemic) cardiomyopathy, ejection fraction (EF) <= 0.30, and QRS duration >= 130 ms.
- The trial aims to compare outcomes between CRT-D recipients and a control group.
Main Results:
- This section is not yet available as the trial is planned.
- Anticipated outcome: a significant reduction in mortality and HF events.
Conclusions:
- The MADIT-CRT trial is expected to provide critical data on CRT-D effectiveness.
- Findings will inform clinical practice for managing heart failure in specific patient groups.
- The study will clarify the role of CRT-D in patients with reduced ejection fraction and conduction delays.
