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Recurrent dysphonia and acitretin.

N Petitpain1, J Pouaha, F Cosserat

  • 1Department of Clinical Pharmacology, University Hospital, Nancy, France. crpv@chu-nancy.fr

Journal of Voice : Official Journal of the Voice Foundation
|November 9, 2005
PubMed
Summary
This summary is machine-generated.

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Acitretin, a medication for skin conditions, may cause voice changes (dysphonia). Symptoms resolved upon stopping the drug and returned when treatment resumed, suggesting a direct drug effect.

Area of Science:

  • Dermatology
  • Pharmacology
  • Otolaryngology

Background:

  • Acitretin is a systemic retinoid used for treating severe psoriasis and other keratinization disorders.
  • Adverse effects of acitretin typically involve mucocutaneous symptoms, but laryngeal effects are not well-documented.

Observation:

  • A patient treated with acitretin developed dysphonia (hoarseness).
  • The dysphonia resolved completely after discontinuation of acitretin.
  • Recurrence of dysphonia was observed upon reintroduction of acitretin.

Findings:

  • This case presents the first reported instance of acitretin-induced dysphonia.
  • The temporal relationship between drug administration, withdrawal, and symptom recurrence strongly suggests a causal link.

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Implications:

  • This finding highlights a potential, previously unrecognized side effect of acitretin.
  • Clinicians should consider dysphonia in patients on acitretin therapy.
  • Further investigation into the mechanism of acitretin's effect on laryngeal mucous membranes is warranted.