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Chitosan drug binding by ionic interaction.

Yaowalak Boonsongrit1, Ampol Mitrevej, Bernd W Mueller

  • 1Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|November 9, 2005
PubMed
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Drug encapsulation in chitosan micro/nanoparticles showed high burst release due to weak ionic interactions. Formulation pH affects entrapment efficiency but not drug release control.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Chitosan micro/nanoparticles are explored for drug delivery.
  • Controlling drug release from these systems remains a challenge.

Purpose of the Study:

  • To prepare drug-chitosan micro/nanoparticles using ionic interaction.
  • To investigate the influence of drug properties and formulation pH on entrapment efficiency and drug release.

Main Methods:

  • Preparation of drug-chitosan micro/nanoparticles using three model drugs (insulin, diclofenac sodium, salicylic acid).
  • Determination of physicochemical properties, entrapment efficiencies, and drug release profiles.
  • Analysis of zeta potential and surface charge in relation to drug entrapment.

Main Results:

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  • Entrapment efficiency was influenced by formulation pH, but maximum efficiency did not correlate with the highest drug ionization.
  • High burst release of drugs was observed from chitosan micro/nanoparticles across different pH conditions.
  • Drug entrapment levels affected zeta potential and surface charge.

Conclusions:

  • The ionic interaction between model drugs and chitosan is insufficient for effective drug release control.
  • While formulation pH can optimize entrapment, it does not mitigate rapid drug release from these systems.