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Related Experiment Video

Updated: May 7, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Severity assessment in asthma: An evolving concept.

Mary K Miller1, Charles Johnson, Dave P Miller

  • 1Genentech, Inc, South San Francisco, CA 94080, USA. mkmiller@gene.com

The Journal of Allergy and Clinical Immunology
|November 9, 2005
PubMed
Summary
This summary is machine-generated.

Asthma severity assessments varied significantly between guidelines and physician evaluations. Patients identified as having severe asthma, regardless of method, showed higher healthcare and medication use, indicating a link between severity perception and resource utilization.

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Area of Science:

  • Pulmonary Medicine
  • Clinical Epidemiology

Background:

  • Accurate asthma severity assessment is crucial for effective treatment.
  • Current guidelines rely on severity assessment for treatment recommendations.
  • Consistency of asthma severity assessment in difficult-to-treat cases is not well-established.

Purpose of the Study:

  • To compare three distinct asthma severity assessment methodologies.
  • To evaluate assessment consistency in patients within the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study.

Main Methods:

  • Compared National Asthma Education and Prevention Program (NAEPP) and Global Initiative for Asthma (GINA) guideline-based assessments with physician evaluations.
  • Derived guideline-based symptom severity from patient questionnaires.
  • Benchmarked assessments against patient-reported medication use and healthcare utilization for asthma exacerbations.
  • Utilized prebronchodilator FEV(1) for lung function assessment.

Main Results:

  • Demonstrated a notable lack of agreement across different asthma severity assessment methods.
  • Confirmed a significant association between perceived asthma severity and healthcare resource consumption.
  • Patients classified as having severe asthma by guidelines or physicians exhibited the highest medication and healthcare usage.

Conclusions:

  • Asthma severity classification based solely on symptoms and lung function may not fully represent a patient's condition.
  • Clinical evaluations should incorporate medication adherence and healthcare resource use for a comprehensive assessment.
  • Further longitudinal research is required to refine optimal asthma severity assessment criteria.