Related Experiment Video

Updated: Aug 14, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

High pulse pressure associated with cardiovascular events in patients with type 2 diabetes undergoing hemodialysis

Lydia Foucan1, Jacqueline Deloumeaux, Kheira Hue

  • 1Research group Clinical Epidemiology and Medicine of the University of Antilles and Guyane. lydia.foucan@chu-guadeloupe.fr

American Journal of Hypertension
|November 11, 2005
PubMed

Insights

Pulse pressure (PP) is strongly associated with cardiovascular events in type 2 diabetes patients undergoing hemodialysis. Targeting predialysis blood pressure is crucial for managing cardiovascular risk in these patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Diabetology

Background:

  • Patients with type 2 diabetes undergoing hemodialysis (HD) face increased cardiovascular (CV) risks.
  • Examining blood pressure parameters like systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) is vital in this population.

Purpose of the Study:

  • To investigate SBP, DBP, MAP, and PP in type 2 diabetes patients on HD.
  • To assess the relationship between these BP parameters and CV events, including coronary heart disease and congestive cardiac failure.

Main Methods:

  • A cross-sectional study included 80 Afro-Caribbean type 2 diabetic patients on HD in Guadeloupe.
  • Pre- and postdialysis blood pressure measurements were recorded.
  • Logistic regression and ROC curve analyses were employed.

Main Results:

  • 30% of patients experienced one or more CV events.
  • Predialysis PP was significantly higher in patients with CV comorbidity (84.5 mmHg) compared to those without (69.5 mmHg).
  • Adjusted analysis revealed a significant association of predialysis PP (OR 2.25) and SBP (OR 1.97) with CV morbidities, with PP showing a stronger association.

Conclusions:

  • Pulse pressure demonstrates the strongest association with cardiovascular morbidities in type 2 diabetes patients on hemodialysis.
  • Therapeutic strategies should consider predialysis blood pressure values, particularly PP, for antihypertensive treatment.
  • Targeting predialysis BP is essential for managing CV risk in this patient group.
Abstract

Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
Blood Pressure01:30

Blood Pressure

Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...