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Related Experiment Videos

Symptoms after accelerated immunisation.

M E Ramsay1, M Rao, N T Begg

  • 1Immunisation Division, PHLS Communicable Disease Surveillance Centre, London.

BMJ (Clinical Research Ed.)
|June 13, 1992
PubMed
Summary
This summary is machine-generated.

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Accelerated diphtheria-tetanus-pertussis (DTP) vaccine schedules in infants resulted in fewer symptoms. This accelerated immunisation approach showed reduced fever and local reactions compared to standard DTP schedules.

Area of Science:

  • Pediatric Vaccinology
  • Immunology
  • Public Health

Background:

  • The standard diphtheria-tetanus-pertussis (DTP) vaccine schedule involves immunisation at later infant ages.
  • Concerns exist regarding potential adverse reactions following DTP vaccination.
  • Optimizing infant immunisation schedules is crucial for both efficacy and safety.

Purpose of the Study:

  • To evaluate the incidence of symptoms following an accelerated diphtheria-tetanus-pertussis (DTP) vaccine schedule.
  • To compare adverse reactions between accelerated and standard DTP immunisation protocols in infants.

Main Methods:

  • A controlled study was conducted comparing an accelerated DTP immunisation schedule (2, 3, and 4 months) with a standard schedule (3, 4.5-5, and 8.5-11 months).
  • Parentally recorded data on symptoms, axillary temperatures, and local injection site reactions (redness, swelling) were collected for seven days post-vaccination.

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  • The study involved 107 children on the accelerated schedule and 115 on the standard schedule.

    • Main Results:

    • Symptoms occurred less frequently overall with the accelerated DTP immunisation schedule.
    • Significantly lower proportions of parents reported axillary temperatures above 37.2°C in the accelerated group after the third vaccine dose.
    • Reduced local reactions, including redness and swelling exceeding 2.5 cm, were observed in infants receiving the accelerated DTP schedule.

    Conclusions:

    • Infant immunisation with diphtheria-tetanus-pertussis (DTP) vaccine at 2, 3, and 4 months of age is associated with fewer adverse reactions.
    • The accelerated DTP schedule appears to be a safer alternative regarding common post-vaccination symptoms.
    • These findings support the implementation of earlier, accelerated DTP vaccination schedules.