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Updated: Aug 14, 2026
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
[Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats]
Lan Luo1, Hui-Jun Yin, Ying Zhang
1Department of Cardiovascular Diseases, Medical College, Jiamusi University, Jiamusi, Heilongjiang Province 154007, China.
Objective:
To observe the effect of ginseng fruit saponins (GFS) on insulin sensitivity index in high fat-fed rats.
Methods:
An animal model of insulin resistance was established by injecting low dose of streptozotocin (STZ) in high fat-fed rats. Effect of GFS on insulin sensitivity was detected with glucose infusion rate (GIR) by euglycemic hyperinsulinemic clamp technique.
Results:
The level of fasting blood glucose and insulin in untreated group increased more significantly than that in normal control group (P<0.05, P<0.01), while the index of GIR decreased significantly (P<0.01). As compared with the untreated groupìthe parameters of GFS-treated groups were improved significantly in a dosage-dependent manner (P<0.05, P<0.01).
Conclusion:
GFS can improve experimental insulin resistance in rats.