Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sarcoidosis.

Adriana A Bonfioli1, Fernando Orefice

  • 1Eye & Ear Institute of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Seminars in Ophthalmology
|November 12, 2005
PubMed
Summary
This summary is machine-generated.

Sarcoidosis is a multisystem granulomatous disease affecting adults, often presenting with lung and eye issues. Early diagnosis and treatment with corticosteroids generally lead to a good visual prognosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T cell immunoregulation in active ocular toxoplasmosis.

Immunology letters·2017
Same author

Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2016
Same author

New drug delivery system for corneal administration of mitomycin-C.

Journal of cataract and refractive surgery·2016
Same author

Increased Submacular Choroidal Thickness in Active, Isolated, Extramacular Toxoplasmosis.

Ophthalmology·2015
Same author

Multimodal Imaging Assisting the Early Diagnosis of Cat-Scratch Neuroretinitis.

Seminars in ophthalmology·2014
Same author

Subconjunctival indocyanine green identifies lymphatic vessels.

JAMA ophthalmology·2014
Same journal

Longitudinal Structural and Functional Trajectories Following Netarsudil Intensification or Surgical Escalation in Primary Open-Angle Glaucoma.

Seminars in ophthalmology·2026
Same journal

Maternal Diabetes Mellitus During Pregnancy as a Risk Factor for Congenital Nasolacrimal Duct Obstruction in the Offspring - a Large-Scale National Study.

Seminars in ophthalmology·2026
Same journal

Clinical Spectrum and Genetics of Ocular Manifestations in Muscle Eye Brain Disease: A Literature Review.

Seminars in ophthalmology·2026
Same journal

Port Delivery System Vs Monthly Ranibizumab in VEGF-Driven Macular Disease: A Systematic Review and Meta-Analysis.

Seminars in ophthalmology·2026
Same journal

Genome Wide Pleiotropic Analysis Reveals Shared Genetic Architecture and Pathological Basis Between Retinitis Pigmentosa and Relevant Ocular Comorbidities.

Seminars in ophthalmology·2026
Same journal

Does QuantiFERON-Positive Tubercular Serpiginous-Like Choroiditis Affect Retinal and Choroidal Structures Differently in Affected Eyes Compared to Fellow Eyes and Healthy Controls? A Comparative OCT and OCT-A Study.

Seminars in ophthalmology·2026
See all related articles

Area of Science:

  • Immunology
  • Ophthalmology
  • Pulmonology

Background:

  • Sarcoidosis is a multisystem granulomatous disease of unknown origin.
  • It affects adults aged 20-40, with higher prevalence in women and US Black populations.
  • Ocular involvement occurs in 25-80% of patients, ranging from the orbit to the posterior eye segments.

Purpose of the Study:

  • To provide a comprehensive overview of sarcoidosis, focusing on its ocular manifestations and management.
  • To highlight diagnostic methods and treatment strategies for sarcoidosis, particularly concerning visual health.

Main Methods:

  • Review of existing literature on sarcoidosis epidemiology, clinical presentation, and diagnosis.
  • Description of typical ocular findings in sarcoidosis, including uveitis and posterior segment disease.

Related Experiment Videos

  • Summary of current treatment approaches, including corticosteroids and cytotoxic agents.

    • Main Results:

    • Sarcoidosis commonly presents with bilateral hilar adenopathy, pulmonary infiltrates, and potential skin or eye involvement.
    • Ocular sarcoidosis can manifest as uveitis with characteristic signs like mutton-fat keratic precipitates and iris nodules.
    • Posterior segment complications include cystoid macular edema, a major cause of vision loss.

    Conclusions:

    • Sarcoidosis diagnosis relies on clinical findings, imaging, and biopsy confirmation of noncaseating granulomas.
    • Ocular sarcoidosis requires prompt management to prevent sight-threatening complications like cystoid macular edema.
    • While systemic corticosteroids are primary treatment, cytotoxic agents are used for refractory cases, with generally good visual outcomes.