Related Experiment Video
Updated: Aug 14, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Lost time, absence costs, and reduced productivity output for employees with bipolar disorder
Nathan L Kleinman1, Richard A Brook, Krithika Rajagopalan
1HCMS Group, Cheyenne, Wyoming 82001, USA. nathan_kleinman@hcmsgroup.com
Objective:
We sought to evaluate the incremental health-related lost work time and at-work productivity loss for employees with bipolar disorder (BPD).
Methods:
Health-related absence and real productivity output of employees with BPD were compared with that of non-BPD and other employee cohorts from a large employer database using multivariate regression to control for cohort differences.
Results:
After adjusting for confounding factors, employees with BPD had significantly higher absence costs (1,219 dollars) and 11.5 additional lost days (P<0.05) per year than those without BPD. Adjusted annual productivity output was 20% lower for the BPD group (P<0.05).
Conclusions:
Employees with BPD are less likely to be present for work. When present, their productivity level is similar to that of other employees, but over the course of a year, their absence rates result in significant productivity losses.
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