Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Redox-dependent transcriptional regulation.

Hongjun Liu1, Renata Colavitti, Ilsa I Rovira

  • 1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Circulation Research
|November 15, 2005
PubMed
Summary

Oxidative stress impacts cellular health and disease. This review explores how cellular redox status regulates transcription factors, impacting cardiovascular health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetically predicted CXCL16 expression is associated with Parkinson's disease risk and peripheral immune cell dysregulation: a two-sample mendelian randomization study.

Molecular brain·2026
Same author

Unanswered questions on palmitic acid-driven neuroimmune inflammation in atopic dermatitis: a commentary on Chen et al.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same author

Ultrafast damage dynamics and ablation mechanism of a BaGa<sub>4</sub>Se<sub>7</sub> crystal induced by femtosecond laser irradiation.

Optics express·2026
Same author

Efficient nutrient removal from low C/N municipal wastewater using a phototrophic biofilm system integrating simultaneous nitrification-denitrification and phosphorus removal (SND).

Environmental research·2026
Same author

Cyclodextrin-Derived Porous Liquids Enabled by In Situ Solvation Shell Formation.

Journal of the American Chemical Society·2026
Same author

Microsurgical Clip Reconstruction of Multiple Contiguous Aneurysms of the Anterior Communicating Artery Complex: Subfrontal Exposure and Endoscopic Verification-A Case Illustration.

Neurosurgery practice·2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Science

Background:

  • Reactive oxygen species (ROS) are implicated in various diseases, including cardiovascular conditions like hypertension and atherosclerosis.
  • Cells respond to oxidative stress by upregulating genes for detoxification and cellular repair.
  • Transcription factors play a crucial role in mediating these cellular responses.

Purpose of the Study:

  • To review recent advancements in understanding how cellular redox status influences transcription-factor activity.
  • To highlight the implications of redox-regulated transcription factors in cardiovascular disease pathogenesis.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of molecular mechanisms linking cellular redox status to transcription factor regulation.

Related Experiment Videos

  • Synthesis of findings related to cardiovascular implications.

    • Main Results:

    • Cellular redox status directly or indirectly modulates transcription factor structure, localization, and DNA binding.
    • This regulation is a key mechanism in the cellular response to oxidative stress.
    • Dysregulation of these pathways contributes to cardiovascular pathologies.

    Conclusions:

    • Understanding the interplay between redox status and transcription factors is vital for cardiovascular disease research.
    • Targeting redox-sensitive transcription factors may offer novel therapeutic strategies for cardiovascular disorders.