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The influence of amphetamine on language activation: an fMRI study
Iris E C Sommer1, Bob Oranje, Nick F Ramsey
1Rudolf Magnus Institute of Neuroscience Psychiatry Department, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands. I.Sommer@azu.nl
Rationale:
Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language.
Methods:
To test this hypothesis, language activation was measured twice with functional magnetic resonance imaging in ten healthy right-handed men in a double-blind crossover design 2 h after amphetamine or placebo administration.
Results:
Language-related activation increased significantly in task-related areas, but the individual lateralization index was not affected in the amphetamine condition as compared to placebo.
Conclusions:
This finding suggests that short-termed alterations in the dopaminergic neurotransmission do not affect language dominance.
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