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Isolated cases of palmoplantar keratoderma, Unna-Thost type
A Kansky1, A Stanimirović, A Basta-Juzbasic
1Department of Dermatology, University of Zagreb, Faculty of Medicine, Croatia.
Cutis
|June 1, 1992
Abstract:
A study on the prevalence of hereditary palmoplantar keratoderma, Unna-Thost type, was carried out in Croatia. Altogether 205 cases were verified, and of these forty-eight were chosen for further studies. Six isolated cases of hereditary palmoplantar keratoderma, Unna-Thost type, were found. The following theories were considered to explain such a phenomenon: spontaneous mutation, reduced gene expression, incomplete penetration of the gene, late onset of the disease, unknown biological father of the proband, and involvement of genes in addition to the autosomal dominant one.