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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:

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Related Experiment Video

Updated: Jun 30, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Update on malignant mesothelioma.

Karen Antman1, Raffit Hassan, Milton Eisner

  • 1Provost, Boston University Medical Campus Dean, Boston University School of Medicine, Boston, Massachusetts 02118, USA. kha4@bu.edu

Oncology (Williston Park, N.Y.)
|November 16, 2005
PubMed
Summary
This summary is machine-generated.

Mesothelioma, a rare cancer often linked to asbestos exposure, affects around 3,000 Americans annually. Recent chemotherapy advancements show improved outcomes for patients with this asbestos-related cancer.

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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Area of Science:

  • Oncology
  • Epidemiology

Background:

  • Mesotheliomas are rare cancers with an incidence of approximately 3,000 new cases per year in the U.S.
  • Most cases are asbestos-related, though radiation and simian virus 40 (SV40) are potential, albeit controversial, factors.
  • Mesotheliomas predominantly affect the pleura (85%) and peritoneum (91%).

Purpose of the Study:

  • To summarize the epidemiology, histology, and prognostic factors of mesothelioma.
  • To highlight recent therapeutic advancements in mesothelioma treatment.

Main Methods:

  • Review of epidemiological data on mesothelioma incidence and mortality.
  • Analysis of histological subtypes and their impact on prognosis.
  • Summary of findings from recent randomized clinical trials on chemotherapy.

Main Results:

  • Mesothelioma incidence and mortality may be underestimated.
  • Epithelial histology is associated with better survival, while multicystic and well-differentiated papillary types have a better prognosis and should be considered separately in trials.
  • Addition of antifolates to platinum-based chemotherapy significantly improves time to progression and survival.

Conclusions:

  • Mesothelioma remains a challenging diagnosis with varied histology and prognosis.
  • Current treatment strategies, particularly chemotherapy combinations, offer improved outcomes for mesothelioma patients.