Related Experiment Video
Updated: Jun 14, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Preparation of a highly stable niosome and its hydrotrope-solubilization action to drugs
1School of Chemistry and Chemical Engineering, Nanjing University, Jinagsu 210093, PR China. tqliu@yzu.edu.cn
Abstract:
Highly stable niosomes are prepared and investigated in Tween80/PEG6000/Span80/H2O system. The mean radius of the niosomes is 0.15-0.2 microm. The contents of PEG6000 and Span80 and the system temperature affect the size and the stability of the niosome. A certain Span80 can remarkably improve the stability. The niosome is provided distinctly with the hydrotrope-solubilization action to the hydrophilic drug and hydrophobic drug, which affects the niosome membrane. The mechanism of the effects of PEG6000 and Span80 on the niosome is discussed in this paper.
Related Concept Videos
The Colloidal State
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability Enhancement: Drug Permeability Enhancement
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

