Related Experiment Video

Updated: Jul 13, 2026

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
06:40

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance

Published on: July 28, 2023

Improved efficacy of 10-Day sequential treatment for Helicobacter pylori eradication in children: a randomized trial

Ruggiero Francavilla1, Elena Lionetti, Stefania Paola Castellaneta

  • 1Department of Biomedicina dell'Età Evolutiva, Università degli Studi di Bari, Bari, Italy. rfrancavilla@libero.it

Gastroenterology
|November 16, 2005
PubMed

Insights

A novel 10-day sequential treatment significantly improved Helicobacter pylori eradication rates in children compared to standard triple therapy. This approach offers a more effective option for pediatric H. pylori infection management.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Standard first-line Helicobacter pylori eradication therapy in children has an approximate 75% success rate.
  • Recent adult studies show a novel 10-day sequential treatment achieves a 95% eradication rate.

Purpose of the Study:

  • To evaluate the efficacy of a 10-day sequential treatment regimen for H. pylori eradication in children.
  • To compare the sequential treatment's eradication rate against conventional triple therapy in pediatric patients.

Main Methods:

  • A randomized study involving 78 children with H. pylori infection.
  • Participants received either 10-day sequential treatment (omeprazole, amoxicillin, clarithromycin, tinidazole) or 7-day triple therapy (omeprazole, amoxicillin, metronidazole).
  • H. pylori infection was confirmed by multiple diagnostic tests, and eradication was assessed via 13C-urea breath test 8 weeks post-therapy.

Main Results:

  • The sequential treatment achieved an H. pylori eradication rate of 97.3% (36/37).
  • The triple therapy group achieved an eradication rate of 75.7% (28/37).
  • The difference in eradication rates between the two groups was statistically significant (P < .02).

Conclusions:

  • The 10-day sequential treatment demonstrated a significantly higher H. pylori eradication rate in children compared to standard triple therapy.
  • These findings in pediatric patients align with successful outcomes observed in adult studies.
  • Sequential treatment represents a more effective therapeutic option for pediatric H. pylori infections.
Abstract

More Related Videos

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance05:23

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis04:56

Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis

Published on: May 16, 2025

Related Concept Videos

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...