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Related Experiment Videos

Continuous flow in open microfluidics using controlled evaporation.

Martin Zimmermann1, Steven Bentley, Heinz Schmid

  • 1IBM Research GmbH, Research Laboratory Zürich, Säumerstrasse 4, 8803, Rüschlikon, Switzerland.

Lab on a Chip
|November 16, 2005
PubMed
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This study introduces a novel method for precisely controlling liquid flow rates in open microfluidic networks. The technique utilizes Peltier elements to manage evaporation, enabling programmable flow for microfluidic assays.

Area of Science:

  • Microfluidics
  • Fluid Dynamics
  • Biotechnology

Background:

  • Open microfluidic networks (MFNs) offer versatile platforms for various assays.
  • Precise control of liquid flow rates is crucial for many microfluidic applications.
  • Existing methods for flow control in MFNs can be complex or limited.

Purpose of the Study:

  • To present a simple and efficient method for programming liquid flow rates in open microfluidic networks.
  • To demonstrate dynamic control over evaporation for flow rate regulation.
  • To enable precise reagent delivery and sample manipulation in microfluidic devices.

Main Methods:

  • Utilized Peltier elements for thermal control of filling ports and capillary pumps in MFNs.
  • Employed cooling Peltier elements to prevent evaporation in filling ports.

Related Experiment Videos

  • Used heating Peltier elements under capillary pumps to induce evaporation and set microchannel flow rates.
  • Integrated ambient temperature and relative humidity as inputs for dynamic evaporation control.

    • Main Results:

    • Achieved programmable flow rates in microchannels ranging from 1.2 nL/s to 30 pL/s.
    • Maintained 90% of a 0.6 µL solution in an open filling port for 60 minutes.
    • Demonstrated a simple and efficient method for dynamic flow rate control in MFNs.

    Conclusions:

    • The developed method provides precise and programmable control of liquid flow in open microfluidic networks.
    • This technique is suitable for a wide range of assays and chemical reactions requiring controlled microfluidic liquid handling.
    • The simplicity and efficiency of the method make it broadly applicable in microfluidic research and development.