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Related Experiment Videos

Ectopic cervical anaplastic ependymoma.

Zhe Wang1, Gaosheng Huang, Peisong Yan

  • 1Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. path1018@fmmu.edu.cn

Pathology International
|November 17, 2005
PubMed
Summary
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This report details the first documented case of a primary ectopic cervical anaplastic ependymoma, a rare central nervous system tumor found outside the brain or spine. The patient achieved a favorable outcome following surgery and radiotherapy.

Area of Science:

  • Neuropathology
  • Surgical Pathology
  • Oncology

Background:

  • Ependymomas are tumors typically originating in the central nervous system (CNS).
  • Primary extraneural ependymomas are exceptionally rare, with limited documented cases.
  • This study focuses on a unique presentation of ependymoma in the head and neck region.

Observation:

  • A 35-year-old male presented with a primary ectopic anaplastic ependymoma in the right cervical root region.
  • No concurrent central nervous system or distant tumors were detected.
  • The tumor exhibited microscopic features of World Health Organization (WHO) grade III anaplastic ependymoma, including cellularity, nuclear atypia, and high mitotic activity.

Findings:

  • Immunohistochemistry confirmed glial fibrillary acidic protein, epithelial membrane antigen (EMA), vimentin, and S-100 protein positivity.

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  • EMA staining demonstrated both membranous and paranuclear immunoreactivity.
  • Electron microscopy revealed tumor cells forming micro rosettes with projecting microvilli and cilia.

    • Implications:

    • This case expands the known spectrum of head and neck neoplasms.
    • It highlights the importance of considering extraneural origins for ependymomas.
    • The successful management with surgery and radiotherapy suggests a viable treatment approach for such rare tumors.