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Cytotoxic clerodane diterpenes from Glossocarya calcicola
Heidi L Rasikari1, David N Leach, Peter G Waterman
1Centre for Phytochemistry and Pharmacology, Southern Cross University, Military Rd., Level 2, Lismore, N.S.W. 2780, Australia. hrasik10@scu.edu.au
Abstract:
Three clerodane diterpenes were isolated and identified from leaf extract of Glossocarya calcicola. Compound has been characterised as (rel)-10betaH-trans-12xi-(2-methylbut-2(E)-enoyl)-1beta-(isobutanoyl)-6alpha,13xi-dihydroxyclerodan-4(20),8(18)-dien-7,15-dione-15,16-oxide, to which we have assigned the trivial name calcicolin-A. The other two compounds had the same skeletal structure and C-12 substituent but in compound, the C-1 esterifying group becomes 2-methylbut-2(E)-enoic acid and in it becomes 2-methylbutanoic acid. Although anti-insect activity was not observed for G. calcicola, cytotoxicity against insect and human carcinoma cell lines was detected.
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