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Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
Temperature Measurement Sites01:14

Temperature Measurement Sites

A thermometer measures body temperature. The common sites for measuring body temperature are the oral cavity, axillary region, temporal artery, and skin surface, such as the forehead, abdomen, and axilla. True core body temperature is assessed in the rectum, tympanic membrane, pulmonary artery, esophagus, and urinary bladder.
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
Requirements for Human Life01:26

Requirements for Human Life

The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Assessing Body Temperature - Temporal Artery01:19

Assessing Body Temperature - Temporal Artery

Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.  
Step 3: Assess the patient's forehead...

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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Short-term temperature excursion does not affect plasma and cryoprecipitate quality.

Kelly M Winter1, Rachel G Webb1, Eugenia Mazur1

  • 1Research and Development, Australian Red Cross Lifeblood, Alexandria, New South Wales, Australia.

Vox Sanguinis
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

Plasma and cryoprecipitate exposed to higher temperatures can still meet quality standards. This study shows these blood components remain safe and effective for up to six months after a temperature excursion.

Keywords:
plasmaqualityshort termtemperature excursion

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Area of Science:

  • Transfusion Medicine
  • Blood Component Quality Assurance
  • Cryobiology

Background:

  • Optimal preservation of plasma and cryoprecipitate requires storage below -25°C.
  • Temperature excursions can lead to discarding valuable blood components.
  • Assessing the impact of temperature deviations is crucial for inventory management.

Purpose of the Study:

  • To evaluate the quality of plasma and cryoprecipitate after a short-term temperature excursion.
  • To determine a potential shelf life for components subjected to temperature fluctuations.
  • To inform transfusion practices regarding temperature-compromised blood products.

Main Methods:

  • Collected apheresis and whole blood-derived fresh frozen plasma (FFP) and cryoprecipitate.
  • Subjected components to a temperature excursion up to -11°C before returning to -25°C storage.
  • Measured key coagulation factors (e.g., FVIII, fibrinogen) and other proteins at baseline, 3, and 6 months post-excursion.

Main Results:

  • Factor VIII (FVIII) concentrations remained stable in both plasma and cryoprecipitate up to 6 months post-excursion.
  • Coagulation times (aPTT, PT) showed minimal, non-significant changes in plasma.
  • Fibrinogen, von Willebrand Factor (VWF), protein C, and IgG levels were stable in plasma and cryoprecipitate.

Conclusions:

  • Plasma and cryoprecipitate that experience a temperature excursion can maintain acceptable quality.
  • These components meet quality control specifications for up to 6 months after a temperature deviation.
  • Findings support extending the usability of temperature-compromised blood products, reducing waste.