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m-[125I]iodoaniline: a useful reagent for radiolabeling biotin

L A Khawli1, A I Kassis

  • 1Department of Radiology (Nuclear Medicine), Harvard Medical School, Shields Warren Radiation Laboratory, Boston, MA 02115.

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|April 1, 1992
PubMed

Keywords:
RadioiodinationBiotin-Avidin SystemTumor TargetingPalladium Catalysis

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...