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The entorhinal cortex plays a role in extinction.

Lia R Bevilaqua1, Juliana S Bonini, Janine I Rossato

  • 1Centro de Memória, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica de Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil.

Neurobiology of Learning and Memory
|November 18, 2005
PubMed
Summary

The entorhinal cortex is crucial for extinguishing learned fear responses. NMDA receptors, protein synthesis, and CaMKII activity in this brain region are necessary for memory extinction.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Memory Research

Background:

  • Learned aversive responses are critical for survival.
  • Understanding the neural mechanisms of memory extinction is vital for treating conditions like PTSD.
  • The entorhinal cortex plays a role in memory formation and retrieval.

Purpose of the Study:

  • To investigate the role of the entorhinal cortex in the extinction of a learned aversive response.
  • To identify the molecular pathways involved in this extinction process within the entorhinal cortex.

Main Methods:

  • Rats were trained in an inhibitory avoidance task.
  • Infusions of various inhibitors (AP5, anisomycin, KN-93, PD-98059) were administered to the entorhinal cortex after the first extinction session.

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  • Extinction of the conditioned response was assessed over consecutive daily test sessions.

    • Main Results:

    • Infusion of NMDA receptor antagonist AP5, protein synthesis inhibitor anisomycin, and CaMKII inhibitor KN-93 into the entorhinal cortex hindered extinction of the learned aversive response.
    • MEK1/2 inhibitor PD-98059 did not affect extinction.
    • These effects were observed regardless of whether the interval between extinction sessions was 24 or 48 hours.

    Conclusions:

    • Normal functionality of NMDA receptors, CaMKII activity, and protein synthesis in the entorhinal cortex are necessary for generating memory extinction.
    • The ERK1/2 pathway does not appear to be involved in this extinction process in the entorhinal cortex.