Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonvascular complications following spinal manipulation.

Jeffrey S Oppenheim1, Daniel E Spitzer, David H Segal

  • 1Section of Neurosurgery, Good Samaritan Hospital, 255 Lafayette Avenue, Suffern, NY 10901, USA. JOPPENHEIM@mac.com

The Spine Journal : Official Journal of the North American Spine Society
|November 18, 2005
PubMed
Summary

Spinal manipulation can lead to serious nonvascular complications, including neurological deficits requiring surgery. Early detection of risk factors and prompt intervention are crucial for managing adverse outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.

Molecular cell·2023
Same author

Defining the susceptibility of colorectal cancers to BH3-mimetic compounds.

Cell death & disease·2020
Same author

Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells.

Cell death and differentiation·2020
Same author

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos.

Blood·2018
Same author

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9.

Bioorganic & medicinal chemistry·2015
Same author

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription.

Blood·2013

Area of Science:

  • Neurology
  • Neurosurgery
  • Spinal Medicine

Background:

  • Spinal manipulation is linked to various vascular and nonvascular complications.
  • Prior research has predominantly focused on vascular issues, leaving nonvascular complications less understood.

Purpose of the Study:

  • To comprehensively outline the spectrum of nonvascular complications after spinal manipulation.
  • To better define the potential risks associated with manipulative treatments.

Main Methods:

  • Retrospective review of medical records and radiographic studies.
  • Analysis of 18 patients presenting with immediate neurological worsening post-spinal manipulation.
  • Comparison of neurological status pre-manipulation, post-manipulation, and post-surgery.

Related Experiment Videos

Main Results:

  • Eighteen patients experienced immediate neurological decline post-spinal manipulation, affecting cervical, thoracic, and lumbar spine.
  • Complications included myelopathy, paraparesis, cauda equina syndrome, and radiculopathy, with 89% requiring surgery.
  • Surgical outcomes were excellent in 50% and good in 37.5%; three deaths resulted from unrecognized malignancies.

Conclusions:

  • Spinal manipulation carries risks of significant nonvascular complications, frequently necessitating surgical intervention.
  • Pretreatment imaging may identify patients at higher risk, such as those with disc herniations or occult malignancies.
  • Urgent evaluation and management are vital for patients experiencing symptom exacerbation or new neurological deficits.