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Enalapril monotherapy in essential hypertension
The Journal of the Association of Physicians of India
|February 1, 1992
Summary
Enalapril effectively lowers blood pressure in adults with essential hypertension. This study found enalapril safe and effective as a first-line treatment, with most patients experiencing significant blood pressure reduction.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Essential hypertension is a prevalent cardiovascular condition requiring effective management.
- Current therapeutic strategies include monotherapy with angiotensin-converting enzyme (ACE) inhibitors.
Purpose of the Study:
- To evaluate the anti-hypertensive efficacy and safety of enalapril in adult patients with essential hypertension.
- To determine the optimal dosage and treatment duration for enalapril monotherapy.
Main Methods:
- A clinical trial involving 30 adults with essential hypertension (systolic BP > 150 mmHg or diastolic BP > 100 mmHg).
- Patients received enalapril at doses ranging from 5-20 mg daily.
- Blood pressure reduction, time to peak effect, and side effects were monitored.
Main Results:
- Of 20 patients who completed the trial, 45% achieved optimal blood pressure (< 130/90 mmHg) and 35% showed significant reduction.
- Mean systolic BP decreased by 32.5 mmHg and diastolic BP by 18.5 mmHg.
- Peak BP reduction occurred within 3.5 weeks with a mean dose of 7.2 mg/day; 40% experienced mild side effects.
Conclusions:
- Enalapril monotherapy demonstrates significant efficacy in reducing blood pressure in patients with essential hypertension.
- Enalapril is a safe and effective option for first-line treatment of essential hypertension.