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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Carcinomatous mediastinitis secondary to carcinoma of the bladder]
1Service de gastroentérologie, Centre Hospitalo-Universitaire Henri Mondor, Créteil. c-locher@ch-meaux.fr
Introduction:
This is the first reported case of a histologically-proved mediastinal metastatic site of a transitional cell carcinoma of the bladder.
Case:
A 61-year-old woman who had undergone a total cystectomy 3 years earlier for transitional cell carcinoma was hospitalized for dysphagia. Endoscopy showed impassable stenosis beginning 25 cm below the dental arch, without any developing endoluminal lesion. Histologic analysis of the biopsy samples identified transitional cell carcinoma infiltration of the muscularis and deep mucosa of the esophagus.
Discussion:
Three years after a diagnosis of bladder cancer, invasion of the paraesophageal lymph nodes was accompanied by infiltration of the esophageal muscularis and contiguous mucosa. Esophageal stenoses by carcinomatous mediastinitis are rare; when they occur, it is usually secondary to breast cancer. They are generally treated endoscopically, which entails a risk of perforation.
