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Transcriptional crosstalk between nuclear receptors and cytokine signal transduction pathways in immunity

Lihua Wang1, Xiaohu Zhang, William L Farrar

  • 1Basic Research Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, USA.

Cellular & Molecular Immunology
|November 19, 2005
PubMed

Insights

Nuclear receptors regulate cytokine production and function through interactions with cytokine-associated transcription factors. This crosstalk is vital for immunity, inflammation, and treating cytokine-related tumors.

Area of Science:

  • Molecular Biology
  • Immunology
  • Endocrinology

Background:

  • Nuclear receptors and cytokine-associated transcription factors are distinct signaling molecules.
  • These factors regulate gene transcription via specific responsive elements.
  • Emerging evidence highlights nuclear receptors as key regulators of cytokine activity.

Purpose of the Study:

  • To review the mechanisms of nuclear receptor action.
  • To explore transcriptional crosstalk between nuclear receptors and cytokine pathways.
  • To emphasize the role of protein-protein interactions in this crosstalk.

Main Methods:

  • Literature review of nuclear receptor and cytokine signaling.
  • Analysis of mechanisms underlying transcriptional crosstalk.
  • Focus on direct and co-regulator-mediated protein interactions.

Main Results:

  • Nuclear receptors directly or indirectly interact with cytokine-associated transcription factors.
  • This crosstalk involves complex protein-to-protein interactions.
  • These interactions modulate cytokine production and function.

Conclusions:

  • Nuclear receptor-cytokine factor crosstalk is a critical mechanism in biological processes.
  • This interaction is essential for immune responses and inflammation.
  • Understanding this crosstalk offers therapeutic potential for cytokine-related diseases and tumors.

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