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Related Experiment Videos

Verbal fluency deficits in multiple sclerosis.

Julie D Henry1, William W Beatty

  • 1School of Psychology, University of New South Wales, Sydney, NSW, Australia. julie.henry@unsw.edu.au

Neuropsychologia
|November 19, 2005
PubMed
Summary
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People with multiple sclerosis (MS) show significant impairments in phonemic and semantic fluency. These verbal fluency deficits are sensitive indicators of cognitive changes in MS.

Area of Science:

  • Neuroscience
  • Psychology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease affecting cognitive functions.
  • Neuropsychological testing is crucial for assessing cognitive deficits in MS.

Purpose of the Study:

  • To quantitatively review studies comparing phonemic and semantic fluency deficits in MS patients versus healthy controls.
  • To compare the magnitude of these deficits with other cognitive measures.

Main Methods:

  • A quantitative review of 35 studies involving 3673 participants.
  • Analysis of deficits in phonemic and semantic fluency tests.
  • Comparison with other cognitive tests like verbal intelligence, naming, Wisconsin Card Sorting Test, and Symbol Digit Modalities Test (SDMT).

Main Results:

Related Experiment Videos

  • Participants with MS exhibited substantial and similar impairments in both phonemic and semantic fluency.
  • These fluency deficits were more pronounced than those in verbal intelligence, naming, and the Wisconsin Card Sorting Test.
  • Deficits were comparable or smaller than those observed on the oral Symbol Digit Modalities Test (SDMT).
  • Increased neurological disability and a chronic progressive disease course correlated with larger fluency deficits.

Conclusions:

  • Phonemic and semantic fluency tests, along with the SDMT, are sensitive measures for detecting cognitive impairment in MS.
  • While disease course and disability correlate with fluency deficits, this is partly explained by confounding factors like age and duration of illness.