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Updated: Aug 14, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Management of patients with cavernous angiomas presenting epileptic seizures
Sadami Noto1, Masami Fujii, Tatsuo Akimura
1Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan.
Background:
The aim of this study was to establish a treatment strategy for patients with cavernous angiomas and have seizures.
Methods:
We analyzed retrospectively 31 patients with cavernous angiomas presenting with seizures. Of the 31 patients, 15 (11 men, 4 women) had been treated medically (the medical group) and 16 (11 men, 5 women) had been treated surgically (the surgical group). The percentage of patients who became seizure-free and the number of anticonvulsants used were compared between these 2 groups. The mean follow-up period was 5.3 years (range, 7 months-10 years). There was no statistically significant difference between the 2 groups with regard to the number of patients, sex, age, and follow-up period.
Results:
The percentage of patients who became seizure-free was higher in the surgical group than in the medical group (80% vs 19%, P < .01). The number of anticonvulsants required was reduced in the surgical group after surgery (from 1.5 +/- 0.7 to 1.1 +/- 0.8, P < .01) and was not reduced after in the medical group.
Conclusions:
Surgical intervention may have greater benefits than medical intervention for patients with cavernous angiomas presenting with epileptic seizures.
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