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[Rheumatoid arthritis and cystic fibrosis].

V Doyen1, C Fournier, N Bautin

  • 1Centre de Ressources et Compétences pour la Mucoviscidose, Clinique des maladies respiratoires, Hôpital Calmette, CHRU, Lille, France.

Revue Des Maladies Respiratoires
|November 19, 2005
PubMed
Summary

Cystic fibrosis (CF) patients show a higher incidence of rheumatoid arthritis (RA). RA progression in CF is linked to bronchial infections and respiratory decline, posing treatment challenges.

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Area of Science:

  • Rheumatology
  • Pulmonology
  • Genetics

Background:

  • Cystic fibrosis (CF) is a genetic disorder primarily affecting the lungs.
  • Inflammatory arthropathies, such as rheumatoid arthritis (RA), are uncommon in CF patients.
  • This study investigates the co-occurrence of RA in adult CF patients.

Observation:

  • Three adult CF patients (2 female, 1 male) developed RA at ages 17, 44, and 19.
  • All patients had CFTR gene mutations (delta F508) and positive sweat tests.
  • RA onset and progression correlated with Staphylococcus aureus colonization, bronchial infection exacerbations, and declining respiratory function (FEV1 53%, 42%, 94%).

Findings:

  • An increased incidence of RA was observed in the studied CF patient population.
  • Positive rheumatoid factor and/or anti-CCP antibodies were detected in affected patients.

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  • RA proved progressive and challenging to treat, with limited success using corticosteroids, methotrexate, and leflunomide.

    • Implications:

    • The findings suggest a potential link between CF and RA, warranting further investigation.
    • Anti-CCP antibodies are valuable diagnostic markers for RA in CF patients.
    • Managing respiratory infections is crucial for controlling RA progression and improving therapeutic outcomes in CF patients.