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Inherent complexities of trace detection by surface-enhanced Raman scattering
Nicholas P W Pieczonka1, Ricardo F Aroca
1Materials and Surface Science Group, Faculty of Science, University of Windsor, N9B 3P4, Windsor, ON, Canada.
Summary
Surface-enhanced Raman scattering (SERS) and SERRS offer sensitive detection but present interpretation challenges. This review compiles common analytical interferences encountered when collecting SERS/SERRS spectra.
Area of Science:
- Optics and Photonics
- Spectroscopy
- Nanotechnology
Background:
- Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) are advanced optical techniques.
- These methods are crucial for ultrasensitive chemical analysis, nanostructure characterization, and single-molecule detection.
- Interpreting SERS/SERRS spectra is complex due to inherent instabilities and contributions.
Purpose of the Study:
- To consolidate and present common analytical interferences in SERS/SERRS.
- To aid researchers in accurately measuring and interpreting SERS/SERRS data.
- To address the challenges associated with SERS/SERRS spectral collection.
Main Methods:
- Literature review and compilation of common interferences.
- Analysis of factors affecting SERS/SERRS spectral quality.
- Categorization of spectral modifications and instabilities.
Main Results:
- Identification of various instabilities affecting SERS/SERRS measurements.
- Explanation of contributions that modify measured spectra.
- Detailed discussion of interferences arising from the enhancement mechanism and experimental conditions.
Conclusions:
- Accurate interpretation of SERS/SERRS spectra requires understanding potential interferences.
- This compilation serves as a reference for researchers in the field.
- Addressing these interferences is key to advancing ultrasensitive chemical analysis using SERS/SERRS.