Related Experiment Video
Updated: Aug 14, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
Impact of dose and volume on radiation-induced mucositis
Giovanna Mantini1, Stefania Manfrida, Francesco Cellini
1Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico "A. Gemelli", Roma, Italy. gmantini@rm.unicatt.it
Abstract:
There is a relationship between a given radiation dose and the resulting biological effect in the management of head and neck cancer. Radiation mucositis represents a frequent complication in cancer chemoradiation. Its prevention and treatment are major goals in radiation therapy schedules. Critical tissues can be spared using high conformal radiation therapy (3DCRT) based on consensus guidelines for target volume. Current approaches to radiation mucositis with respect to the dose and volume impact are illustrated. The monitoring system of late toxicity used by the authors is presented.
Related Concept Videos
Biological Effects of Radiation
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Dose-Response Relationship: Overview
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Pharmacokinetic–Pharmacodynamic Relationship: Dose to Pharmacological Effect
