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Related Experiment Videos

Phosphaturic mesenchymal tumor: a case report.

Anupma Nayak1, Shree Gopal Sharma, Nikhil Tandon

  • 1All India Institute of Medical Sciences, New Delhi.

Indian Journal of Pathology & Microbiology
|November 22, 2005
PubMed
Summary

Tumor-induced osteomalacia is rare, but surgical removal of the tumor can rapidly resolve symptoms. This case highlights a phosphaturic mesenchymal tumor causing osteomalacia in a 66-year-old male.

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Osteomalacia is a condition characterized by impaired bone mineralization.
  • Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome.
  • TIO is typically caused by mesenchymal tumors that secrete fibroblast growth factor 23 (FGF23).

Observation:

  • A 66-year-old male presented with clinical features of osteomalacia.
  • The patient's presentation was associated with a phosphaturic mesenchymal tumor, mixed connective tissue variant.
  • This specific tumor type is an uncommon cause of TIO.

Findings:

  • Resection of the phosphaturic mesenchymal tumor led to significant improvement in the patient's osteomalacia symptoms.
  • The case underscores the link between specific mesenchymal tumors and mineral metabolism disorders.

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  • Histopathological analysis confirmed the tumor as a mixed connective tissue variant.

    • Implications:

    • Early diagnosis and surgical management of TIO can lead to favorable outcomes.
    • Understanding rare tumor variants is crucial for diagnosing and treating TIO.
    • This case contributes to the literature on rare causes of osteomalacia and paraneoplastic syndromes.