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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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Partial duplication of head--a rare congenital anomaly

Manikkapurath Hemachandran1, Bishan Dass Radotra

  • 1Department of Histopathology, Post Graduate Institute of Medical Education & Research, Chandigarh.

Indian Journal of Pathology & Microbiology
|November 22, 2005
PubMed

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Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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Genomic Imprinting and Inheritance

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