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FAB classification of leukemia: a cytochemical study.

Jai Shree Sharma1, Shobha Mohindroo

  • 1Department of Pathology, I.G.M.C., Shimla.

Indian Journal of Pathology & Microbiology
|November 22, 2005
PubMed
Summary

This study evaluated the French-American-British (FAB) classification for acute leukemia. Including cytochemical stains significantly improved diagnostic accuracy compared to morphology alone.

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Area of Science:

  • Hematology
  • Oncology
  • Clinical Pathology

Background:

  • Accurate classification of acute leukemia is crucial for effective treatment.
  • The French-American-British (FAB) classification is a widely used system.
  • Assessing the reproducibility of diagnostic criteria is essential for clinical practice.

Purpose of the Study:

  • To evaluate the reproducibility of the modified FAB classification for acute leukemia.
  • To determine the impact of cytochemical stains on diagnostic accuracy.

Main Methods:

  • Reviewed 36 cases of acute leukemia using peripheral and bone marrow smears.
  • Applied modified FAB classification criteria.
  • Utilized cytochemical stains: myeloperoxidase (MPO), Sudan Black B (SBB), Periodic acid Schiff's (PAS), and Alpha-naphthyl acetate esterase (ANAE).

Main Results:

  • Morphological assessment alone achieved 75% concordance.
  • Inclusion of cytochemical stains improved concordance to 92%.
  • Cytochemistry significantly enhanced the reliability of FAB classification.

Conclusions:

  • Modified FAB classification is reproducible for acute leukemia diagnosis.
  • Cytochemical stains are vital for improving the accuracy of acute leukemia classification.
  • Integration of morphology and cytochemistry offers a more reliable diagnostic approach.

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