Related Experiment Videos
Bone marrow biopsy in Hodgkin's disease
Seema Sharma1, Arun Ahuja, Manjula Murari
1Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. ssharma@sgpgi.ac.in
Indian Journal of Pathology & Microbiology
|November 22, 2005
Summary
Bone marrow biopsies are crucial for staging untreated Hodgkin
Area of Science:
- Oncology
- Hematology
Background:
- Hodgkin's disease (HD) is a lymphoma affecting the lymphatic system.
- Accurate staging is essential for effective treatment planning in HD.
Purpose of the Study:
- To evaluate the incidence and patterns of bone marrow involvement in untreated Hodgkin's disease.
- To determine the diagnostic utility of bone marrow biopsy in assessing disease spread.
Main Methods:
- Retrospective analysis of bone marrow biopsies from 58 untreated Hodgkin's disease patients.
- Correlation of bone marrow involvement with clinical stage, age, sex, and histological subtype.
Main Results:
- Bone marrow involvement was detected in 36.2% of patients.
- Marrow positivity was higher in advanced clinical stages (III and IV), younger patients (<15 years), and males.
- Mixed cellularity subtype showed the highest incidence of marrow involvement; lymphocytic predominance showed none.
- Focal infiltration was more common than diffuse infiltration.
- Bone marrow aspiration smears were frequently negative despite positive trephine biopsy findings.
Conclusions:
- Bone marrow biopsy, particularly trephine biopsy, is a valuable and simple tool for assessing disease spread in Hodgkin's disease.
- Bone marrow involvement is associated with specific demographic and clinical factors in HD patients.