Related Experiment Video

Updated: Aug 14, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

[Cardiovascular risk factors in children with type 1 diabetes and their relationship with the glycemic control]

Adela V Abregu1, Teresita del R Carrizo, Maria M Prado

  • 1Cátedra de Práctica Hospitalaria, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán. vabregu@arnet.com.ar

Medicina
|November 22, 2005
PubMed

Insights

Children with type 1 diabetes have higher cardiovascular disease risks. Poor glycemic control in pediatric diabetics is linked to dyslipidemia and elevated fibrinogen, emphasizing early detection and strict metabolic management.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Cardiology

Context:

  • Type 1 diabetes (T1D) significantly increases cardiovascular disease (CVD) risk in children.
  • Pediatric T1D management requires understanding associated cardiovascular risk factors.
  • Glycemic control is a critical determinant of long-term health outcomes in diabetic children.

Purpose:

  • To assess cardiovascular risk factors in children with T1D.
  • To investigate the association between glycemic control and CVD risk markers.
  • To compare risk factors between well-controlled and poorly controlled diabetic children and healthy controls.

Summary:

  • Diabetic children (5-15 years) exhibited elevated total cholesterol, LDL-cholesterol, and HDL-cholesterol compared to controls.
  • Eighty-three percent of diabetic children had poor glycemic control (HbA1c ≥ 8%).
  • Poor glycemic control correlated with higher plasma fibrinogen levels, while lipid profiles showed minimal differences except for HDL-cholesterol.

Impact:

  • Identifies dyslipidemia and hyperglycemia as primary CVD risk factors in pediatric T1D.
  • Highlights the need for early screening of cardiovascular risk markers in diabetic children.
  • Underscores the importance of stringent metabolic control to mitigate CVD risk in this population.

Related Concept Videos

Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...