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Related Experiment Videos

Buccal drug delivery.

John D Smart1

  • 1School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton BN2 4GJ, UK. john.smart@brighton.ac.uk

Expert Opinion on Drug Delivery
|November 22, 2005
PubMed
Summary
This summary is machine-generated.

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Buccal drug delivery offers enhanced absorption but faces challenges with large molecules. Overcoming these barriers requires new technologies for effective systemic delivery via the buccal mucosa.

Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Buccal formulations aim for prolonged local therapy and enhanced systemic drug delivery.
  • The buccal mucosa presents a significant barrier to drug absorption, particularly for large biopharmaceutical molecules like proteins and oligonucleotides.
  • Current buccal drug delivery is limited to small, lipophilic molecules due to absorption challenges.

Purpose of the Study:

  • To review the development and challenges of buccal drug delivery systems.
  • To explore the potential of the buccal route for delivering larger molecules and overcoming absorption barriers.
  • To identify the need for advanced technologies to improve buccal systemic delivery.

Main Methods:

  • Review of existing literature on buccal formulations and bioadhesive polymers.

Related Experiment Videos

  • Analysis of challenges associated with buccal mucosa drug penetration.
  • Discussion of second-generation bioadhesives and site-specific ligands.

    • Main Results:

    • Various buccal formulations (tablets, patches, liquids, semisolids) have been developed, but few reached the market.
    • Bioadhesive polymers, including advanced second-generation types with ligands, are crucial for buccal retention and delivery.
    • The buccal route is currently restricted to small lipophilic molecules, highlighting limitations for larger therapeutics.

    Conclusions:

    • The buccal route holds significant potential for systemic delivery of diverse active agents if absorption barriers are overcome.
    • Patient acceptability and successful systemic delivery of large molecules (proteins, oligonucleotides, polysaccharides) remain key challenges.
    • Development of novel or improved technologies is essential to realize the full potential of buccal drug delivery for advanced therapeutics.