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Pre-formed vascularized bone grafts using polyethelyne chambers.

S Mizumoto1, Y Inada, A J Weiland

  • 1Department of Orthopaedic Surgery, Hospital for Special Surgery, Cornell University Medical College, New York, NY 10021.

Journal of Reconstructive Microsurgery
|July 1, 1992
PubMed
Summary
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This study investigated vascularized bone grafts in rabbits. Vascular pedicle ligation led to graft necrosis, indicating free vascularized bone grafts are not viable long-term.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Corticocancellous bone chips in vascularized chambers form pre-formed bone grafts.
  • The viability of transferring these as free vascularized bone grafts requires investigation.

Purpose of the Study:

  • To determine if pre-formed vascularized bone grafts can be transferred as island or free grafts.
  • To examine the material properties and long-term viability of these grafts after transfer.

Main Methods:

  • Cylindrical polyethylene chambers filled with bone chips were implanted in rabbit thighs with saphenous vessels.
  • Distal vascular pedicle ligation was performed at 3, 6, 9, and 12 weeks to simulate free graft transfer.
  • Contralateral non-ligated sides served as controls.

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Main Results:

  • Control grafts showed bony bridging by 7 weeks and solid bone by 10 weeks, but with significant resorption.
  • Vascular pedicle ligation resulted in thrombosis and necrosis of the newly formed bone.
  • Bone resorption was significant even in successful grafts by 13 weeks.

Conclusions:

  • Free transfer of these vascularized bone grafts leads to graft necrosis due to vascular compromise.
  • Significant bone resorption limits the long-term success of these grafts, even without transfer.