Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longitudinal change in memory performance associated with HTR2A polymorphism.

Chandra A Reynolds1, Mårten Jansson, Margaret Gatz

  • 1Department of Psychology, University of California at Riverside, 1344 Olmsted Hall, Riverside, CA 92521-0426, USA. chandra.reynolds@ucr.edu

Neurobiology of Aging
|November 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond proximity: how food quality in dollar and grocery stores influences health.

BMC public health·2026
Same author

Dementia risk by metabolic health and obesity in two prospective cohorts.

BMC medicine·2026
Same author

The long reach of childhood income inequality: a multinational twin study of gene-environment interplay on adult depressive symptoms.

Psychological medicine·2026
Same author

Genetic and Environmental Associations Between Processing Speed and Executive Functions Across Adolescence and Established Adulthood.

Behavior genetics·2026
Same author

Neighborhood disadvantage and cognitive function in older adults: The moderating role of young adult general cognitive ability.

Health & place·2026
Same author

Cognitive dispersion in established adulthood: etiology and implications for cognitive aging.

Innovation in aging·2026
Same journal

Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated.

Neurobiology of aging·2026
Same journal

How cognition and hearing-related measures covary with hippocampal subfield features from structural MRI in younger and older adults.

Neurobiology of aging·2026
Same journal

Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals.

Neurobiology of aging·2026
Same journal

Review of current research practices in social and structural determinants of health data collection in Canadian longitudinal cohorts of aging and dementia.

Neurobiology of aging·2026
Same journal

Global brain maintenance predicts well-preserved cognitive function: A pooled analysis of three longitudinal population-based Swedish cohorts.

Neurobiology of aging·2026
Same journal

Midlife insulin resistance and brain beta-amyloid accumulation as predictors of change in late-life cognitive function - A 20-year follow-up study.

Neurobiology of aging·2026
See all related articles

Genetic influences on memory in aging adults are linked to the HTR2A gene. A specific HTR2A polymorphism is associated with better longitudinal memory performance and slower decline in older adults.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychology

Background:

  • Quantitative genetic studies indicate moderate genetic influences on memory in aging adults.
  • Previous research linked a HTR2A gene polymorphism to episodic memory in young adults.

Purpose of the Study:

  • To investigate the association between a HTR2A gene polymorphism and longitudinal memory performance in older adults.
  • To examine the role of the 5-HT2A serotonin receptor in episodic memory formation in aging individuals.

Main Methods:

  • Analysis of growth curve parameters in the Swedish Adoption/Twin Study of Aging (SATSA).
  • Examined association between a HTR2A polymorphism and longitudinal memory performance across age.

Main Results:

Related Experiment Videos

  • The HTR2A gene polymorphism was associated with both baseline figural memory performance at age 65 and nonlinear changes in memory performance over time.
  • Individuals with two copies of the common G allele showed higher longitudinal figural memory performance compared to those with the less frequent A allele.
  • Performance trajectories differed by 2-6% annually between genotypes.

    • Conclusions:

    • Findings suggest a role for the 5-HT2A serotonin receptor in the formation of episodic memories in older adults.
    • The HTR2A gene may influence cognitive trajectories related to memory in aging populations.