Related Experiment Video
Updated: Aug 14, 2026

Murine Kidney Transplant Technique
Published on: October 20, 2015
Do recipients of kidneys from donors treated with streptokinase develop anti-streptokinase antibodies?
1Department of Renal and Liver Transplant, The Freeman Hospital, High Heaton, Newcastle Upon Tyne NE7 7DN, United Kingdom. D.Talbot@ncl.ac.uk
Abstract:
Streptokinase is used for preflush for non-heart-beating donors (NHBDs) in our center. The aim of this study was to evaluate whether the use of thrombolytic streptokinase results in the production of anti-streptokinase antibodies in the recipients after renal transplantation. Recipient sera taken prior to and at 1 and 6 months posttransplant were tested for the presence of antibodies to streptokinase using an enzyme-linked immunosorbent assay assay. No differences were detected between a group of 18 recipients who had kidneys from thrombolytic-treated NHBDs and a further group of 18 who received NHBD kidneys without such treatment.
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