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J type diabetes revisited.

E Y Morrison1, D Ragoobirsingh

  • 1Department of Biochemistry, Faculty of Medical Sciences, University of the West Indies, Kingston, Jamaica.

Journal of the National Medical Association
|July 1, 1992
PubMed
Summary
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Phasic insulin-dependent diabetes mellitus (PIDDM) may be a distinct diabetes subtype. Studies show reduced insulin binding, kidney damage, and altered pancreatic appearance in PIDDM, suggesting it

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Diabetology

Background:

  • J type diabetes, a subtype of malnutrition-related diabetes (protein-deficient pancreatic diabetes, PDPD), has seen limited recent reports.
  • Phasic insulin-dependent diabetes mellitus (PIDDM) has been described in Jamaica, potentially representing a related syndrome.

Purpose of the Study:

  • To investigate the distinct identity of PIDDM compared to Type I and Type II diabetes mellitus.
  • To compare clinical and functional parameters between PIDDM patients and healthy controls.

Main Methods:

  • Comparative analysis of insulin receptor binding in blood cells.
  • Assessment of renal, hepatic, and pancreatic function.
  • Abdominal ultrasonography to evaluate pancreatic morphology.

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Main Results:

  • Significantly decreased insulin binding to white and red blood cells in PIDDM patients (P < .05).
  • Evidence of extensive kidney damage in PIDDM individuals (P < .05).
  • Increased pancreatic echogenicity observed via ultrasonography in PIDDM.

Conclusions:

  • Findings support PIDDM as a distinct syndrome separate from Type I and Type II diabetes.
  • PIDDM shares characteristics with J type diabetes and PDPD, including insulin resistance, absence of ketosis, and intermittent insulin needs, suggesting they are the same entity.