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Updated: Aug 14, 2026

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia
Published on: August 1, 2025
Mast cells modulate maintained neuronal activity in the thalamus in vivo
Péter Kovács1, István Hernádi, Márta Wilhelm
1University of Pécs, Department of Experimental Zoology and Neurobiology, 6 Ifjúság str., H-7624, Pécs, Hungary. pkovacs@gamma.ttk.pte.hu
Abstract:
Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.
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