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To 'B' regulated: B cells as members of the regulatory workforce

Pau Serra1, Pere Santamaria

  • 1Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

Trends in Immunology
|November 23, 2005
PubMed

Until recently, immune regulation was thought to be predominantly mediated by specialized subsets of T lymphocytes. However, although B lymphocytes have previously been shown to have regulatory properties in autoimmunity, a recent report by Knoechel et al. establishes a role for B lymphocytes in the control of pathogenic autoreactive T cell responses arising when the number of lymphocytes is abnormally low (lymphopenia).

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