Related Experiment Video
Updated: Aug 14, 2026
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Experimental model of gastroesophageal reflux in rats
Edmilson Vieira Gaia Filho1, Alberto Goldenberg, Henrique Oliveira Costa
1Escola de Ciências Médicas de Alagoas, UNCISAL, Brazil. edmilsongaia@uol.com.br
Purpose:
To develop an experimental model of gastroesophageal reflux in rats.
Methods:
Sixty Wistar rats underwent surgery and were assigned to one of the three groups of twenty animals each. The animals in group A underwent total esophageal myectomy and, in group (B), underwent partial myectomy. The third group was the control group (C). A contrast radiographic study of the esophagus was performed to evaluate gastroesophageal reflux. The anatomopathological study of the esophagus was used to evaluate esophagitis.
Results:
During the 30-day postoperative follow-up, 14 animals in group A presented with reflux of barium in the esophagus. The presence of barium in the esophagus was observed in 7 animals in group B and in 2 animals in the control group. The result of the histopathology examination was controversial. A marked weight loss in the rats undergoing total myectomy was observed, however there was no significant statistical difference.
Conclusion:
Total myectomy in the lower third of the esophagus caused gastroesophageal reflux in the majority of the animals.
