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[Problems of prophylaxis and treatment of infectious complications in reconstructive surgery]

N S Bogomolova, T D Oreshkina, L V Bolshakov

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |November 24, 2005
    PubMed

    Insights

    Polyresistant gram-positive bacteria pose a significant challenge in reconstructive surgery. Linezolid demonstrated 100% effectiveness against these pathogens in a study, proving safe for pediatric use.

    Area of Science:

    • Infectious Diseases
    • Surgical Infections
    • Antimicrobial Resistance

    Background:

    • Polyresistant staphylococci, streptococci, and enterococci are a major cause of infectious complications in reconstructive surgery.
    • These resistant strains constituted 58.4-59.7% of isolates between 1999-2004, highlighting a growing clinical problem.

    Purpose of the Study:

    • To evaluate the efficacy and safety of linezolid in treating and preventing infectious complications caused by polyresistant gram-positive pathogens in reconstructive surgery patients.
    • To assess the potential for step-by-step therapy with linezolid in this patient population.

    Main Methods:

    • Susceptibility testing was performed on 195 clinical isolates.
    • Linezolid was administered to 28 patients undergoing reconstructive surgery, including those requiring artificial circulation.
    • Clinical outcomes and side effects, particularly in pediatric cases, were monitored.

    Main Results:

    • All tested isolates (100%) were susceptible to linezolid.
    • Linezolid proved highly effective in both prophylaxis and treatment of infections caused by polyresistant gram-positive pathogens.
    • No adverse side effects were observed in pediatric patients treated with linezolid.

    Conclusions:

    • Linezolid is a highly effective therapeutic option for managing infectious complications stemming from polyresistant gram-positive bacteria in reconstructive surgery.
    • Step-by-step treatment protocols utilizing linezolid are feasible.
    • Linezolid exhibits a favorable safety profile, even in pediatric populations.

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