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Related Experiment Videos

Amodiaquine polymeric membrane electrode.

T Kimbeni Malongo1, B Blankert, O Kambu

  • 1Université Libre de Bruxelles, Institute of Pharmacy, Bd. du Triomphe, Campus Plaine, C.P. 205/6, 1050 Brussels, Belgium.

Journal of Pharmaceutical and Biomedical Analysis
|November 24, 2005
PubMed
Summary

New poly(vinyl chloride) (PVC) membrane sensors offer a fast and stable method for determining amodiaquine hydrochloride (ADQ.2HCl) in pharmaceutical samples. These sensors provide accurate results, validated against pharmacopoeial methods.

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Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Materials Science

Background:

  • Amodiaquine hydrochloride (ADQ.2HCl) is an antimalarial drug requiring accurate quantification.
  • Development of selective and sensitive electrochemical sensors is crucial for pharmaceutical analysis.

Purpose of the Study:

  • To construct and characterize two types of poly(vinyl chloride) (PVC) membrane sensors for amodiaquine hydrochloride (ADQ.2HCl) determination.
  • To evaluate the performance of these sensors in pharmaceutical dosage forms and dissolution studies.

Main Methods:

  • Fabrication of PVC membrane ion-selective electrodes using ion-pairs of ADQ.2HCl with sodium tetraphenyl borate (NaTPB) or potassium tetrakis(4-chlorophenyl) borate (KTCPB).
  • Investigation of various plasticizers (DOP, NPOE, DOPP, EHA) to optimize sensor performance.

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  • Electrochemical characterization including response range, slope, and pH stability.
  • Assay of ADQ.2HCl in tablets and reconstituted powder, and dissolution profile studies.

    • Main Results:

    • Sensors exhibited fast, stable, and near-Nernstian responses over a wide ADQ concentration range (3.2 x 10(-6) to 2.0 x 10(-2) M).
    • Slopes ranged from 28.5 to 31.4 mV dec(-1) within a pH range of 3.7 to 5.5.
    • Accurate quantification of ADQ.2HCl in pharmaceutical formulations with high average recoveries (104.3% and 99.9%).
    • Good selectivity was observed, though berberine chloride caused significant interference.

    Conclusions:

    • The developed PVC membrane sensors are effective tools for the quantitative determination of amodiaquine hydrochloride in pharmaceutical products.
    • The sensors demonstrate potential for use in quality control and dissolution testing of amodiaquine-based medications.
    • Further research could explore methods to mitigate interference from compounds like berberine chloride.