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Clinical performance of 'no rub' multi-purpose solutions.
Mary Jo Stiegemeier1, Ronald Cedrone, David Evans
1imdocstieg@aol.com
Summary
Regimen 1, an eye care solution, demonstrated superior subjective comfort and satisfaction compared to Regimen 2. Regimen 1 also showed reduced corneal staining and less protein buildup on contact lenses.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Optometry
Background:
- Multi-purpose solutions (MPS) are widely used for soft contact lens care.
- Evaluating the performance of 'no rub' MPS is crucial for patient satisfaction and ocular health.
- Different contact lens materials (FDA Group II and IV) may interact differently with MPS.
Purpose of the Study:
- To compare the subjective comfort and satisfaction, corneal staining, and lens deposits of two 'no rub' MPS.
- To assess the performance of MPS with FDA Group II and Group IV soft contact lenses.
- To determine differences in residual lysozyme on lenses after care with different MPS.
Main Methods:
- A multi-site, double-masked, bilateral crossover study involving 231 subjects.
- Subjects used two 'no rub' MPS (Regimen 1 and Regimen 2) with FDA Group II and Group IV lenses for 28-day periods.
- Evaluations included subjective ratings, corneal staining assessment, and measurement of residual lysozyme on lenses.
Main Results:
- Regimen 1 showed significantly better subjective comfort and satisfaction than Regimen 2 (P < 0.05).
- Corneal staining was significantly higher with the Group II, Regimen 2 combination (P < 0.0001).
- Group IV lenses treated with Regimen 1 had significantly less residual lysozyme (562 µg) compared to Regimen 2 (1145 µg; P < 0.0001).
Conclusions:
- Differences in performance exist between the two 'no rub' MPS evaluated.
- Regimen 1 appears to offer advantages in subjective experience and lens cleanliness.
- Consideration of these performance differences is important when recommending MPS for contact lens wearers.