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A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
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Heat Stroke and Pregnancy
Zackary Bailey1, David Evans2, Collin Hu3
1Womack Family Medicine Residency Program, Womack Army Medical Center, Fort Bragg, NC.
Summary
A pregnant woman suffered severe heat stroke during a high-intensity event, experiencing significant liver and muscle damage. Prompt medical care and rest led to a full recovery for both mother and pregnancy, but she remains high-risk for future heat injuries.
Area of Science:
- Sports Medicine
- Environmental Health
- Obstetrics
Background:
- Heat injuries pose significant risks, especially during physically demanding activities.
- Pregnancy can alter physiological responses to environmental stressors like heat.
- Certain supplements and pre-event behaviors may exacerbate heat injury risk.
Purpose of the Study:
- To report a case of severe heat stroke in a pregnant athlete.
- To highlight the diagnostic and management challenges of heat injury during pregnancy.
- To assess the impact of heat stroke on pregnancy viability and maternal recovery.
Main Methods:
- Case report of a 33-year-old pregnant woman with heat stroke.
- Clinical assessment including laboratory tests (AST, ALT, CK, BUN, Cr) and urinalysis.
- Monitoring of maternal and fetal well-being throughout hospitalization and follow-up.
Main Results:
- The patient experienced heat stroke with markedly elevated liver enzymes (AST/ALT up to 8k) and creatine kinase (CK up to 36k).
- Initial renal function was mildly impaired but normalized with fluid resuscitation.
- Despite initial concerns, the pregnancy remained viable, and the patient recovered fully with conservative management, though with residual muscle soreness and elevated markers.
- Follow-up showed normalization of CK, AST, and ALT levels, with the pregnancy proceeding normally.
Conclusions:
- Heat stroke in pregnant athletes requires careful management due to potential risks to both mother and fetus.
- Prompt medical intervention and rest are crucial for recovery.
- Patients with a history of severe heat injury, especially during pregnancy, are at high risk for recurrence and may benefit from heat tolerance testing.
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