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Related Experiment Videos

The metabolic syndrome: one step forward, two steps back.

Sun H Kim1, Gerald M Reaven

  • 1Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5406, USA.

Diabetes & Vascular Disease Research
|November 25, 2005
PubMed
Summary

Insulin resistance increases cardiovascular disease risk. This review compares the World Health Organization (WHO) and Adult Treatment Panel III (ATP III) definitions of metabolic syndrome, questioning their clinical utility.

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Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Disease Risk Factors
  • Public Health Guidelines

Background:

  • Insulin resistance is linked to glucose intolerance, dyslipidemia, and hypertension.
  • This cluster of metabolic abnormalities increases cardiovascular disease risk.
  • The World Health Organization (WHO) and Adult Treatment Panel III (ATP III) proposed diagnostic criteria for metabolic syndrome.

Purpose of the Study:

  • To critically evaluate the similarities and differences between WHO and ATP III metabolic syndrome definitions.
  • To assess the clinical utility of existing metabolic syndrome diagnostic criteria.
  • To raise awareness of cardiovascular disease risk associated with metabolic syndrome.

Main Methods:

  • Comparative analysis of diagnostic criteria from WHO and ATP III.

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  • Literature review of studies on metabolic syndrome and cardiovascular risk.
  • Critical evaluation of the clinical applicability of proposed definitions.

    • Main Results:

    • WHO and ATP III share the term 'metabolic syndrome' but differ in diagnostic criteria and institutional goals.
    • The definitions vary in their approach to identifying individuals at risk.
    • The clinical utility of both sets of criteria is questioned.

    Conclusions:

    • Metabolic syndrome diagnosis criteria from WHO and ATP III have notable differences.
    • The practical clinical value of these distinct diagnostic approaches requires further scrutiny.
    • Understanding these differences is crucial for accurate risk assessment and patient management.